With the barrage of information coming at us — as well as an increasingly noisy world — how do we know what’s important and what isn’t?
A new study shows how the brain separates relevant from irrelevant information.
“It is critical to our everyday life that our brain processes the most important information out of everything presented to us,” said Xiao-Jing Wang, Global Professor of Neural Science at New York University and New York University Shanghai and the study’s senior author. “Within an extremely complicated neural circuit in the brain, there must be a gating mechanism to route relevant information to the right place at the right time.”
The analysis, based on a computational model, focuses on inhibitory neurons — the brain’s traffic cops that help ensure proper neurological responses to incoming stimuli by suppressing other neurons and working to balance excitatory neurons, which aim to stimulate neuronal activity.
“Our model uses a fundamental element of the brain circuit, involving multiple types of inhibitory neurons, to achieve this goal,” Wang explained. “Our computational model shows that inhibitory neurons can enable a neural circuit to gate in specific pathways of information while filtering out the rest.”
In the analysis, led by Guangyu Robert Yang, a doctoral candidate in Wang’s lab, the researchers devised a model that maps out a more complicated role for inhibitory neurons than had previously been suggested.
Of particular interest to the team was a specific subtype of inhibitory neurons that targets the excitatory neurons’ dendrites — components of a neuron where inputs from other neurons are located. These dendrite-targeting inhibitory neurons are labeled by a biological marker called somatostatin and can be studied selectively by scientists.
The researchers proposed that they not only control the overall inputs to a neuron, but also the inputs from individual pathways, for example, the visual or auditory pathways converging onto a neuron.
“This was thought to be difficult because the connections from inhibitory neurons to excitatory neurons appeared dense and unstructured,” Yang said. “A surprising finding from our study is that the precision required for pathway-specific gating can be realized by inhibitory neurons.”
The researchers used computational models to show that even with the seemingly random connections, these dendrite-targeting neurons can gate individual pathways by aligning with excitatory inputs through different pathways. They showed that this alignment can be realized through synaptic plasticity, a brain mechanism for learning through experience.
The study was published in the journal Nature Communications.
Source: New York University
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October 2, 2016 at 01:23AM
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